POSH Stimulates the Ubiquitination and the Clathrin-independent Endocytosis of ROMK1 Channels

POSH (plenty of SH3) is a scaffold protein that has been shown to act as an E3 ubiquitin ligase. Here we report that POSH stimulates the ubiquitination of Kir1.1 (ROMK) and enhances the internalization of this potassium channel. Immunostaining reveals the expression of POSH in the renal cortical col...

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Detalhes bibliográficos
Main Authors: Lin, Dao-Hong, Yue, Peng, Pan, Chu-Yang, Sun, Peng, Zhang, Xin, Han, Zeguang, Roos, Marcel, Caplan, Michael, Giebisch, Gerhard, Wang, Wen-Hui
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Membrane Transport, Structure, Function, and Biogenesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785594/
https://ncbi.nlm.nih.gov/pubmed/19710010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.041582
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