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Complex N-Linked Glycans on Asn-89 of Kaposi Sarcoma Herpes Virus-encoded Interleukin-6 Mediate Optimal Function by Affecting Cytokine Protein Conformation

Kaposi sarcoma-associated herpesvirus-encoded interleukin-6 (vIL-6) and its human cellular homologue (huIL-6) share similar biological functions. Our previous work showed that N-linked glycosylation was required for optimal function of vIL6 but not huIL-6 (1). Here we describe heterogeneity in the c...

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Detalhes bibliográficos
Main Authors: Dela Cruz, Charles S., Viswanathan, Srinivas R., El-Guindy, Ayman S., Shedd, Duane, Miller, George
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785557/
https://ncbi.nlm.nih.gov/pubmed/19690161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.039115
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