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Transcriptional regulation by AIRE: molecular mechanisms of central tolerance
The negative selection of T cells in the thymus is necessary for the maintenance of self tolerance. Thymic medullary epithelial cells have a key function in this process as they express a large number of tissue-specific self antigens that are presented to developing T cells. Mutations in the transcr...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2785478/ https://ncbi.nlm.nih.gov/pubmed/19008896 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nri2450 |
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