Toxoplasma gondii Cathepsin L Is the Primary Target of the Invasion-inhibitory Compound Morpholinurea-leucyl-homophenyl-vinyl Sulfone Phenyl

The protozoan parasite Toxoplasma gondii relies on post-translational modification, including proteolysis, of proteins required for recognition and invasion of host cells. We have characterized the T. gondii cysteine protease cathepsin L (TgCPL), one of five cathepsins found in the T. gondii genome....

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Библиографические подробности
Главные авторы: Larson, Eric T., Parussini, Fabiola, Huynh, My-Hang, Giebel, Jonathan D., Kelley, Angela M., Zhang, Li, Bogyo, Matthew, Merritt, Ethan A., Carruthers, Vern B.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2009
Предметы:
Enzyme Catalysis and Regulation
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785372/
https://ncbi.nlm.nih.gov/pubmed/19596863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.003780
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