Inhibition of NF-κB-dependent Transcription by MKP-1: TRANSCRIPTIONAL REPRESSION BY GLUCOCORTICOIDS OCCURRING VIA p38 MAPK

Acting via the glucocorticoid receptor (GR), glucocorticoids exert potent anti-inflammatory effects partly by repressing inflammatory gene transcription occurring via factors such as NF-κB. In the present study, the synthetic glucocorticoid, dexamethasone, induces expression of MKP-1 (mitogen-activa...

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Hlavní autoři: King, Elizabeth M., Holden, Neil S., Gong, Wei, Rider, Christopher F., Newton, Robert
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2009
Témata:
Mechanisms of Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785369/
https://ncbi.nlm.nih.gov/pubmed/19648110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.028381
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