Use of Uteroglobin for the Engineering of Polyvalent, Polyspecific Fusion Proteins

We report a novel strategy to engineer and express stable and soluble human recombinant polyvalent/polyspecific fusion proteins. The procedure is based on the use of a central skeleton of uteroglobin, a small and very soluble covalently linked homodimeric protein that is very resistant to proteolyti...

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Detalhes bibliográficos
Main Authors: Ventura, Elisa, Sassi, Francesca, Fossati, Sara, Parodi, Arianna, Blalock, William, Balza, Enrica, Castellani, Patrizia, Borsi, Laura, Carnemolla, Barbara, Zardi, Luciano
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785352/
https://ncbi.nlm.nih.gov/pubmed/19632988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.025924
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