Production of hyperpolarized [1,4-(13)C(2)]malate from [1,4-(13)C(2)]fumarate is a marker of cell necrosis and treatment response in tumors

Dynamic nuclear polarization of (13)C-labeled cell substrates has been shown to massively increase their sensitivity to detection in NMR experiments. The sensitivity gain is sufficiently large that if these polarized molecules are injected intravenously, their spatial distribution and subsequent con...

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Detalhes bibliográficos
Main Authors: Gallagher, Ferdia A., Kettunen, Mikko I., Hu, De-En, Jensen, Pernille R., in ‘t Zandt, René, Karlsson, Magnus, Gisselsson, Anna, Nelson, Sarah K., Witney, Timothy H., Bohndiek, Sarah E., Hansson, Georg, Peitersen, Torben, Lerche, Mathilde H., Brindle, Kevin M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785247/
https://ncbi.nlm.nih.gov/pubmed/19903889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0911447106
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