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Hydrophobic Core Mutations Associated with Cataract Development in Mice Destabilize Human γD-Crystallin
The human eye lens is composed of fiber cells packed with crystallins up to 450 mg/ml. Human γD-crystallin (HγD-Crys) is a monomeric, two-domain protein of the lens central nucleus. Both domains of this long lived protein have double Greek key β-sheet folds with well packed hydrophobic cores. Three...
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| Główni autorzy: | , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
American Society for Biochemistry and Molecular Biology
2009
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2785171/ https://ncbi.nlm.nih.gov/pubmed/19758984 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.031344 |
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