Impaired PTPN13 phosphatase activity in spontaneous or HPV-induced squamous cell carcinomas potentiates oncogene signaling via the MAP kinase pathway

Human papillomaviruses (HPV's) are a causative factor in over 90% of cervical and 25% of head and neck squamous cell carcinomas (HNSCC's). The C-terminus of the high risk HPV 16 E6 oncoprotein physically associates with and degrades a non-receptor protein tyrosine phosphatase (PTPN13), and...

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Autori principali: Hoover, Andrew C, Strand, Gwen L, Nowicki, Paul N, Anderson, Mary E, Vermeer, Paola D, Klingelhutz, Al J, Bossler, Aaron D, Pottala, James V, Hendriks, Wiljan J A J, Lee, John H
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785129/
https://ncbi.nlm.nih.gov/pubmed/19734941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2009.251
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