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Apoptotic Non–β Cells Suppress β Cell Antigen–Reactive T Cells and Induce β Cell Antigen–Specific Regulatory T Cells: Transfusion of Apoptotic Splenic Stromal Cells Prevents Type 1 Diabetes

Steady-state cell apoptosis plays an important role in maintenance of self-tolerance. Based on this notion, the use of apoptotic cells to restore self-tolerance to β cell antigens is a rational approach to type 1 diabetes (T1D) prevention. Our previous study demonstrated that transfusion of apoptoti...

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Autori principali: Xia, Chang-Qing, Qiu, Yushi, Peng, Ruihua, Lo-Dauer, Jeannette, Clare-Salzler, Michael J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785112/
https://ncbi.nlm.nih.gov/pubmed/19120288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1196/annals.1447.038
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