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The stabilization and release of hirudin from liposomes or lipid-assemblies coated with hydrophobically modified dextran
Hirudin is a 65-amino acid peptide and the most potent and specific known inhibitor of thrombin (K(i)=0.2 pM). The short elimination half-life of hirudin from the body (1 hour) necessitates the use of a sustained and controlled delivery system. A proliposome method was used to entrap hirudin in lipo...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer-Verlag
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2784830/ https://ncbi.nlm.nih.gov/pubmed/14727852 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/pt010103 |
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