Estrogen partially down regulates PTEN to prevent apoptosis in VSC4.1 motoneurons following exposure to IFN-γ

PTEN is a tumor suppressor gene that is either mutated or deleted in a number of human cancers. PTEN acts as a negative regulator of the PI3K/Akt survival pathway and thus plays an important role in cell fate, proliferation, growth, and migration. Recent evidence suggests that PTEN may also be invol...

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Hauptverfasser: Smith, Joshua A., Zhang, Ran, Varma, Abhay K., Das, Arabinda, Ray, Swapan K., Banik, Naren L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2784273/
https://ncbi.nlm.nih.gov/pubmed/19748493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainres.2009.09.016
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