Widespread Activation of the DNA Damage Response in Human Pancreatic Intraepithelial Neoplasia

Pancreatic intraepithelial neoplasia (PanIN) lesions are the most common non-invasive precursors of pancreatic adenocarcinoma. We postulated that accumulating DNA damage within the PanIN epithelium activates checkpoint mechanisms. Tissue microarrays were constructed from 81 surgically resected prima...

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Detalhes bibliográficos
Main Authors: Koorstra, Jan-Bart M., Hong, Seung-Mo, Shi, Chanjuan, Meeker, Alan K., Ryu, Ji Kon, Offerhaus, G. Johan A., Goggins, Michael G., Hruban, Ralph H., Maitra, Anirban
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2784029/
https://ncbi.nlm.nih.gov/pubmed/19668150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/modpathol.2009.114
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