A novel DNMT3B splice variant expressed in tumor and pluripotent cells modulates genomic DNA methylation patterns and displays altered DNA binding

DNA methylation is an epigenetic mark essential for mammalian development, genomic stability, and imprinting. DNA methylation patterns are established and maintained by three DNA methyltransferases: DNMT1, DNMT3A, and DNMT3B. Interestingly, all three DNMTs make use of alternative splicing. DNMT3B ha...

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Autori principali: Gopalakrishnan, Suhasni, Van Emburgh, Beth O., Shan, Jixiu, Su, Zhen, Fields, C. Robert, Vieweg, Johannes, Hamazaki, Takashi, Schwartz, Philip H., Terada, Naohiro, Robertson, Keith D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2783805/
https://ncbi.nlm.nih.gov/pubmed/19825994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-09-0018
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