SOX2 Is an Amplified Lineage Survival Oncogene in Lung and Esophageal Squamous Cell Carcinomas

Lineage survival oncogenes are activated by somatic DNA alterations in cancers arising from the cell lineages in which these genes play a role in normal development.1,2 Here we show that a peak of genomic amplification on chromosome 3q26.33, found in squamous cell carcinomas (SCCs) of the lung and e...

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Auteurs principaux: Bass, Adam J., Watanabe, Hideo, Mermel, Craig H., Yu, Soyoung, Perner, Sven, Verhaak, Roel G., Kim, So Young, Wardwell, Leslie, Tamayo, Pablo, Gat-Viks, Irit, Ramos, Alex H., Woo, Michele S., Weir, Barbara A., Getz, Gad, Beroukhim, Rameen, O’Kelly, Michael, Dutt, Amit, Rozenblatt-Rosen, Orit, Dziunycz, Piotr, Komisarof, Justin, Chirieac, Lucian R., LaFargue, Christopher J., Scheble, Veit, Wilbertz, Theresia, Ma, Changqing, Rao, Shilpa, Nakagawa, Hiroshi, Stairs, Douglas B., Lin, Lin, Giordano, Thomas J., Wagner, Patrick, Minna, John D., Gazdar, Adi F., Zhu, Chang Qi, Brose, Marcia S., Cecconello, Ivan, Ribeiro, Ulysses, Marie, Suely K., Dahl, Olav, Shivdasani, Ramesh A., Tsao, Ming-Sound, Rubin, Mark A., Wong, Kwok K., Regev, Aviv, Hahn, William C., Beer, David G., Rustgi, Anil K., Meyerson, Matthew
Format: Artigo
Langue:Inglês
Publié: 2009
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2783775/
https://ncbi.nlm.nih.gov/pubmed/19801978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.465
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