Coronavirus N Protein N-Terminal Domain (NTD) Specifically Binds the Transcriptional Regulatory Sequence (TRS) and Melts TRS-cTRS RNA Duplexes

All coronaviruses (CoVs), including the causative agent of severe acute respiratory syndrome (SARS), encode a nucleocapsid (N) protein that harbors two independent RNA binding domains of known structure, but poorly characterized RNA binding properties. We show here that the N-terminal domain (NTD) o...

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Detalhes bibliográficos
Main Authors: Grossoehme, Nicholas E., Li, Lichun, Keane, Sarah C., Liu, Pinghua, Dann, Charles E., Leibowitz, Julian L., Giedroc, David P.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Ltd. 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2783395/
https://ncbi.nlm.nih.gov/pubmed/19782089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2009.09.040
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