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LGI1-associated epilepsy through altered ADAM23-dependent neuronal morphology

Most epilepsy genes encode ion channels, but the LGI1 gene responsible for Autosomal Dominant Partial Epilepsy with Auditory Features produces a secreted protein. LGI1 is suggested to regulate PSD-95 via ADAM22. However, no unbiased screen of LGI1 action has been conducted. Here, we searched for bra...

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Detalles Bibliográficos
Main Authors: Owuor, Katherine, Harel, Noam Y., Englot, Dario C., Hisama, Fuki, Blumenfeld, Hal, Strittmatter, Stephen M.
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2783222/
https://ncbi.nlm.nih.gov/pubmed/19796686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mcn.2009.09.008
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