IL-12 deficiency suppresses 12-O-tetradecanoylphorbol-13-acetate-induced skin tumor development in 7,12-dimethylbenz(a)anthracene-initiated mouse skin through inhibition of inflammation

Interleukin (IL)-12 deficiency exacerbates tumorigenesis in ultraviolet (UV) radiation-induced skin. Here, we assessed the effects of IL-12 deficiency on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced tumor promotion in 7,12-dimethylbenz(a)anthracene (DMBA)-initiated mouse skin. Using this two-s...

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Detalhes bibliográficos
Main Authors: Sharma, Som D., Meeran, Syed M., Katiyar, Nandan, Tisdale, George B., Yusuf, Nabiha, Xu, Hui, Elmets, Craig A., Katiyar, Santosh K.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2009
Assuntos:
Carcinogenesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2783006/
https://ncbi.nlm.nih.gov/pubmed/19759192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgp228
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