High-Throughput Screening of a 100,000 Compound Library for Inhibitors of Influenza A virus (H3N2)

Using a highly reproducible and robust cell-based HTS assay, the authors screened a 100,000 compound library at 14 and 114 μM compound concentration against influenza strain A/Udorn/72 (H3N2). The “hit” rates (>50% inhibition of the viral cytopathic effect) from the 14 and 114 μM screens were 0.0...

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Autors principals: Severson, William E., McDowell, Michael, Ananthan, Subramaniam, Chung, Dong-Hoon, Rasmussen, Lynn, Sosa, Melinda I., White, E. Lucile, Noah, James, Jonsson, Colleen B.
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2782602/
https://ncbi.nlm.nih.gov/pubmed/18812571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1087057108323123
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