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Inhibition of ErbB2(Her2) expression with small molecule transcription factor mimics

Small molecules that mimic the transcriptional activation domain of eukaryotic transcriptional activators have the potential to serve as effective inhibitors of transcriptional processes. Here we show that one class of transcriptional activation domain mimics, amphipathic isoxazolidines, can be conv...

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Autori principali: Lee, Lori W., Taylor, Christopher C.E., Desaulniers, Jean-Paul, Zhang, Manchao, Højfeldt, Jonas W., Pan, Quintin, Mapp, Anna K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2782467/
https://ncbi.nlm.nih.gov/pubmed/19782563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.08.090
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