Hydrogen-Exchange Mass Spectrometry Reveals Activation-Induced Changes in the Conformational Mobility of p38α MAP Kinase

Hydrogen–deuterium exchange measurements represent a powerful approach to investigating changes in conformation and conformational mobility in proteins. Here, we examine p38α MAP kinase (MAPK) by hydrogen-exchange (HX) mass spectrometry to determine whether changes in conformational mobility may be...

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Detalhes bibliográficos
Main Authors: Sours, Kevin M., Kwok, Stan C., Rachidi, Thami, Lee, Thomas, Ring, Adam, Hoofnagle, Andrew N., Resing, Katheryn A., Ahn, Natalie G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2782421/
https://ncbi.nlm.nih.gov/pubmed/18501927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.04.044
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