Differential actions of ethanol and trichloroethanol at sites in the M3 and M4 domains of the NMDA receptor GluN2A (NR2A) subunit

BACKGROUND AND PURPOSE: Alcohol produces its behavioural effects in part due to inhibition of N-methyl-d-aspartate (NMDA) receptors in the CNS. Previous studies have identified amino acid residues in membrane-associated domains 3 (M3) and 4 (M4) of the NMDA receptor that influence ethanol sensitivit...

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Bibliographic Details
Main Authors: Salous, AK, Ren, H, Lamb, KA, Hu, X-Q, Lipsky, RH, Peoples, RW
Format: Artigo
Language:Inglês
Published: Blackwell Publishing Ltd 2009
Subjects:
Research Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2782349/
https://ncbi.nlm.nih.gov/pubmed/19788495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2009.00397.x
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