Characterization of gene-activated human acid-β-glucosidase: Crystal structure, glycan composition, and internalization into macrophages

Gaucher disease, the most common lysosomal storage disease, can be treated with enzyme replacement therapy (ERT), in which defective acid-β-glucosidase (GlcCerase) is supplemented by a recombinant, active enzyme. The X-ray structures of recombinant GlcCerase produced in Chinese hamster ovary cells (...

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Detalhes bibliográficos
Main Authors: Brumshtein, Boris, Salinas, Paul, Peterson, Brian, Chan, Victor, Silman, Israel, Sussman, Joel L, Savickas, Philip J, Robinson, Gregory S, Futerman, Anthony H
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2010
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2782181/
https://ncbi.nlm.nih.gov/pubmed/19741058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/glycob/cwp138
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