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Predicting drug pharmacokinetics and effect in vascularized tumors using computer simulation

In this paper, we investigate the pharmacokinetics and effect of doxorubicin and cisplatin in vascularized tumors through two-dimensional simulations. We take into account especially vascular and morphological heterogeneity as well as cellular and lesion-level pharmacokinetic determinants like P-gly...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Sinek, John P., Sanga, Sandeep, Zheng, Xiaoming, Frieboes, Hermann B., Ferrari, Mauro, Cristini, Vittorio
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer-Verlag 2008
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2782117/
https://ncbi.nlm.nih.gov/pubmed/18781304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00285-008-0214-y
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