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Unusual Water-mediated Antigenic Recognition of the Proinflammatory Cytokine Interleukin-18
The unique cytokine interleukin-18 (IL-18) acts synergistically with IL-12 to regulate T-helper 1 and 2 lymphocytes and, as such, seems to underlie the pathogenesis of various autoimmune and allergic diseases. Several anti-IL-18 agents are in clinical development, including the recombinant human ant...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2782040/ https://ncbi.nlm.nih.gov/pubmed/19553661 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.023887 |
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