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Unusual Water-mediated Antigenic Recognition of the Proinflammatory Cytokine Interleukin-18

The unique cytokine interleukin-18 (IL-18) acts synergistically with IL-12 to regulate T-helper 1 and 2 lymphocytes and, as such, seems to underlie the pathogenesis of various autoimmune and allergic diseases. Several anti-IL-18 agents are in clinical development, including the recombinant human ant...

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Bibliographische Detailangaben
Hauptverfasser: Argiriadi, Maria A., Xiang, Tao, Wu, Chengbin, Ghayur, Tariq, Borhani, David W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2009
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2782040/
https://ncbi.nlm.nih.gov/pubmed/19553661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.023887
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