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Identification of Residues in the Drug Translocation Pathway of the Human Multidrug Resistance P-glycoprotein by Arginine Mutagenesis

P-glycoprotein (P-gp, ATP-binding cassette B1) is a drug pump that extracts toxic drug substrates from the plasma membrane and catalyzes their ATP-dependent efflux. To map the residues in the drug translocation pathway, we performed arginine-scanning mutagenesis on all transmembrane (TM) segments (t...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Loo, Tip W., Bartlett, M. Claire, Clarke, David M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2009
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2782001/
https://ncbi.nlm.nih.gov/pubmed/19581304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.023267
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