Altered brain neurotransmitter receptors in transgenic mice expressing a portion of an abnormal human Huntington disease gene

Loss of neurotransmitter receptors, especially glutamate and dopamine receptors, is one of the pathologic hallmarks of brains of patients with Huntington disease (HD). Transgenic mice that express exon 1 of an abnormal human HD gene (line R6/2) develop neurologic symptoms at 9–11 weeks of age throug...

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Autores principales: Cha, Jang-Ho J., Kosinski, Christoph M., Kerner, Julie A., Alsdorf, Stephen A., Mangiarini, Laura, Davies, Stephen W., Penney, John B., Bates, Gillian P., Young, Anne B.
Formato: Artigo
Lenguaje:Inglês
Publicado: The National Academy of Sciences 1998
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC27817/
https://ncbi.nlm.nih.gov/pubmed/9600992
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