Depletion of Selenoprotein GPx4 in Spermatocytes Causes Male Infertility in Mice

Phospholipid hydroperoxide glutathione peroxidase (GPx4) is an intracellular antioxidant enzyme that directly reduces peroxidized phospholipids. GPx4 is strongly expressed in the mitochondria of testis and spermatozoa. We previously found a significant decrease in the expression of GPx4 in spermatoz...

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Detalhes bibliográficos
Main Authors: Imai, Hirotaka, Hakkaku, Nao, Iwamoto, Ryo, Suzuki, Jyunko, Suzuki, Toshiyuki, Tajima, Yoko, Konishi, Kumiko, Minami, Shintaro, Ichinose, Shizuko, Ishizaka, Kazuhiro, Shioda, Seiji, Arata, Satoru, Nishimura, Masuhiro, Naito, Shinsaku, Nakagawa, Yasuhito
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Lipids and Lipoproteins: Metabolism, Regulation, and Signaling
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2781666/
https://ncbi.nlm.nih.gov/pubmed/19783653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.016139
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