Structural Mapping of Post-translational Modifications in Human Interleukin-24: ROLE OF N-LINKED GLYCOSYLATION AND DISULFIDE BONDS IN SECRETION AND ACTIVITY

Human interleukin-24 (IL-24) is unique among the IL-10 superfamily as there is considerable evidence that it possesses multiple anti-cancer properties, including direct tumor cell cytotoxicity, helper T cell (TH1) immune stimulation, and anti-angiogenic activities. The primary sequence of human IL-2...

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Bibliografske podrobnosti
Main Authors: Fuson, Kerry L., Zheng, Mingzhong, Craxton, Molly, Pataer, Abujiang, Ramesh, Rajagopal, Chada, Sunil, Sutton, R. Bryan
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2009
Teme:
Protein Synthesis, Post-Translational Modification, and Degradation
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2781607/
https://ncbi.nlm.nih.gov/pubmed/19734147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.036061
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