Crowded Cell-like Environment Accelerates the Nucleation Step of Amyloidogenic Protein Misfolding

To understand the role of a crowded physiological environment in the pathogenesis of neurodegenerative diseases, we report the following. 1) The formation of fibrous aggregates of the human Tau fragment Tau-(244–441), when hyperphosphorylated by glycogen synthase kinase-3β, is dramatically facilitat...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Zhou, Zheng, Fan, Jun-Bao, Zhu, Hai-Li, Shewmaker, Frank, Yan, Xu, Chen, Xi, Chen, Jie, Xiao, Geng-Fu, Guo, Lin, Liang, Yi
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2009
Schlagworte:
Protein Structure and Folding
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2781570/
https://ncbi.nlm.nih.gov/pubmed/19748895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.002832
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