Activator of G Protein Signaling 8 (AGS8) Is Required for Hypoxia-induced Apoptosis of Cardiomyocytes: ROLE OF Gβγ AND CONNEXIN 43 (CX43)

Ischemic injury of the heart is associated with activation of multiple signal transduction systems including the heterotrimeric G-protein system. Here, we report a role of the ischemia-inducible regulator of Gβγ subunit, AGS8, in survival of cardiomyocytes under hypoxia. Cultured rat neonatal cardio...

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Detalhes bibliográficos
Main Authors: Sato, Motohiko, Jiao, Qibin, Honda, Takashi, Kurotani, Reiko, Toyota, Eiji, Okumura, Satoshi, Takeya, Tatsuo, Minamisawa, Susumu, Lanier, Stephen M., Ishikawa, Yoshihiro
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Mechanisms of Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2781539/
https://ncbi.nlm.nih.gov/pubmed/19723622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.014068
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