Cooperative Transcriptional Regulation of the Essential Pancreatic Islet Gene NeuroD1 (Beta2) by Nkx2.2 and Neurogenin 3

Nkx2.2 and NeuroD1 are two critical regulators of pancreatic β cell development. Nkx2.2 is a homeodomain transcription factor that is essential for islet cell type specification and mature β cell function. NeuroD1 is a basic helix-loop-helix transcription factor that is critical for islet β cell mat...

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Main Authors: Anderson, Keith R., Torres, Ciara A., Solomon, Keely, Becker, Thomas C., Newgard, Christopher B., Wright, Christopher V., Hagman, James, Sussel, Lori
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2009
Teme:
Molecular Basis of Cell and Developmental Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2781522/
https://ncbi.nlm.nih.gov/pubmed/19759004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.048694
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