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Cooperative Transcriptional Regulation of the Essential Pancreatic Islet Gene NeuroD1 (Beta2) by Nkx2.2 and Neurogenin 3
Nkx2.2 and NeuroD1 are two critical regulators of pancreatic β cell development. Nkx2.2 is a homeodomain transcription factor that is essential for islet cell type specification and mature β cell function. NeuroD1 is a basic helix-loop-helix transcription factor that is critical for islet β cell mat...
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| Auteurs principaux: | , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Biochemistry and Molecular Biology
2009
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2781522/ https://ncbi.nlm.nih.gov/pubmed/19759004 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.048694 |
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