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Cyclin A/cdk2 Regulates Adenomatous Polyposis Coli-dependent Mitotic Spindle Anchoring

Mutations in adenomatous polyposis coli (APC) protein is a major contributor to tumor initiation and progression in several tumor types. These mutations affect APC function in the Wnt-β-catenin signaling and influence mitotic spindle anchoring to the cell cortex and orientation. Here we report that...

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Detalhes bibliográficos
Main Authors: Beamish, Heather, de Boer, Leonore, Giles, Nichole, Stevens, Frankie, Oakes, Vanessa, Gabrielli, Brian
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2781448/
https://ncbi.nlm.nih.gov/pubmed/19703905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.042820
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