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Transgenically Induced GAD Tolerance Curtails the Development of Early β-Cell Autoreactivities but Causes the Subsequent Development of Supernormal Autoreactivities to Other β-Cell Antigens
OBJECTIVE: To study how tolerance to GAD65 affects the development of autoimmunity to other β-cell autoantigens (β-CAAs) in GAD65-transgenic (GAD-tg) NOD mice. RESEARCH DESIGN AND METHODS: We used ELISPOT to characterize the frequency and functional phenotype of T-cell responses to GAD65 and other β...
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Main Authors: | , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
American Diabetes Association
2009
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2780885/ https://ncbi.nlm.nih.gov/pubmed/19741165 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db08-0851 |
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