Adenovirus E3 MHC inhibitory genes but not TNF/Fas apoptotic inhibitory genes expressed in β cells prevent autoimmune diabetes

To mimic events and molecules involved in type 1 insulin-dependent diabetes mellitus (T1D), we previously designed a transgenic (tg) mouse model where the viral nucleoprotein (NP) gene of lymphocytic choriomeningitis virus (LCMV) was expressed in the thymus to delete high affinity antiself (virus) T...

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Autors principals: Horwitz, Marshall S., Efrat, Shimon, Christen, Urs, von Herrath, Matthias G., Oldstone, Michael B. A.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2009
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2780797/
https://ncbi.nlm.nih.gov/pubmed/19887639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0910648106
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