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Hydrodynamic gene delivery of baboon trypanosome lytic factor eliminates both animal and human-infective African trypanosomes

Several species of African trypanosomes cause fatal disease in livestock, but most cannot infect humans due to innate trypanosome lytic factors (TLFs). Human TLFs are pore forming high-density lipoprotein (HDL) particles that contain apolipoprotein L-I (apoL-I) the trypanolytic component, and haptog...

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Détails bibliographiques
Auteurs principaux: Thomson, Russell, Molina-Portela, Pilar, Mott, Helen, Carrington, Mark, Raper, Jayne
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2009
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2780755/
https://ncbi.nlm.nih.gov/pubmed/19858474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0905669106
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