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Hydrodynamic gene delivery of baboon trypanosome lytic factor eliminates both animal and human-infective African trypanosomes

Several species of African trypanosomes cause fatal disease in livestock, but most cannot infect humans due to innate trypanosome lytic factors (TLFs). Human TLFs are pore forming high-density lipoprotein (HDL) particles that contain apolipoprotein L-I (apoL-I) the trypanolytic component, and haptog...

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Detalhes bibliográficos
Main Authors: Thomson, Russell, Molina-Portela, Pilar, Mott, Helen, Carrington, Mark, Raper, Jayne
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2780755/
https://ncbi.nlm.nih.gov/pubmed/19858474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0905669106
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