Molecular MRI of Cardiomyocyte Apoptosis with Simultaneous Delayed Enhancement MRI Distinguishes Apoptotic and Necrotic Myocytes In Vivo: Potential for Midmyocardial Salvage in Acute Ischemia

BACKGROUND: A novel dual contrast molecular MRI technique to image both cardiomyocyte (CM) apoptosis and necrosis in-vivo within 4-6 hours of ischemia is presented. The technique utilizes the annexin-based nanoparticle AnxCLIO-Cy5.5 (apoptosis) and simultaneous delayed enhancement (DE) imaging with...

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Detalhes bibliográficos
Main Authors: Sosnovik, David E., Garanger, Elisabeth, Aikawa, Elena, Nahrendorf, Matthias, Figuiredo, Jose-Luiz, Dai, Guangping, Reynolds, Fred, Rosenzweig, Anthony, Weissleder, Ralph, Josephson, Lee
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2780438/
https://ncbi.nlm.nih.gov/pubmed/19920044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCIMAGING.109.859678
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