Anaplastic lymphoma kinase: role in cancer pathogenesis and small-molecule inhibitor development for therapy

Anaplastic lymphoma kinase (ALK), a receptor tyrosine kinase in the insulin receptor superfamily, was initially identified in constitutively activated oncogenic fusion forms – the most common being nucleophosmin-ALK – in anaplastic large-cell lymphomas, and subsequent studies have identified ALK fus...

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Hoofdauteurs: Webb, Thomas R, Slavish, Jake, George, Rani E, Look, A Thomas, Xue, Liquan, Jiang, Qin, Cui, Xiaoli, Rentrop, Walter B, Morris, Stephan W
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2009
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2780428/
https://ncbi.nlm.nih.gov/pubmed/19275511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1586/14737140.9.3.331
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