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Effects of dietary cholesterol and simvastatin on cholesterol synthesis in Smith-Lemli-Opitz syndrome (SLOS)

Deficient cholesterol and/or excessive 7-dehydrocholesterol (7-DHC) may be responsible for the pathology of Smith-Lemli-Opitz syndrome (SLOS). Both high cholesterol diets given to ameliorate cholesterol deficiency while decreasing 7-DHC, and cholesterol-enriched diets plus simvastatin to further dec...

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Autors principals: Chan, Yen-Ming, Merkens, Louise S., Connor, William E., Roullet, Jean-Baptiste, Penfield, Jennifer A., Jordan, Julia M., Steiner, Robert D., Jones, Peter J.H.
Format: Artigo
Idioma:Inglês
Publicat: 2009
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2780332/
https://ncbi.nlm.nih.gov/pubmed/19430384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1203/PDR.0b013e31819ea4eb
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