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Enzymatic regulation of pattern: BMP4 binds CUB domains of Tolloids and inhibits proteinase activity
In Xenopus embryos, a dorsal–ventral patterning gradient is generated by diffusing Chordin/bone morphogenetic protein (BMP) complexes cleaved by BMP1/Tolloid metalloproteinases in the ventral side. We developed a new BMP1/Tolloid assay using a fluorogenic Chordin peptide substrate and identified an...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Cold Spring Harbor Laboratory Press
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2779747/ https://ncbi.nlm.nih.gov/pubmed/19884260 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1839309 |
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