CpG-island promoters drive transcription of human telomeres

The longstanding dogma that telomeres, the heterochromatic extremities of linear eukaryotic chromosomes, are transcriptionally silent was overturned by the discovery that DNA-dependent RNA polymerase II (RNAPII) transcribes telomeric DNA into telomeric repeat-containing RNA (TERRA). Here, we show th...

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Main Authors: Nergadze, Solomon G., Farnung, Benjamin O., Wischnewski, Harry, Khoriauli, Lela, Vitelli, Valerio, Chawla, Raghav, Giulotto, Elena, Azzalin, Claus M.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Cold Spring Harbor Laboratory Press 2009
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2779677/
https://ncbi.nlm.nih.gov/pubmed/19850908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.1748309
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