Up-regulation of intermediate calcium-activated potassium channels (IKCa), counterbalances the impaired endothelium-dependent vasodilation in SHRSP

Endothelial dysfunction has been linked to a decrease in nitric oxide (NO) bioavailability and attenuated endothelium-derived hyperpolarizing factor (EDHF)-mediated relaxation. The small (SK(Ca)) and intermediate (IK(Ca)) calcium-activated potassium channels play a key role in endothelium-dependent...

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Detalhes bibliográficos
Main Authors: Giachini, Fernanda R.C., Carneiro, Fernando S., Lima, Victor V., Carneiro, Zidonia N., Dorrance, Anne, Webb, R. Clinton, Tostes, Rita C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2779552/
https://ncbi.nlm.nih.gov/pubmed/19766962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.trsl.2009.07.003
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