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Perspective on Free-Energy Perturbation Calculations for Chemical Equilibria

An overview is provided on the computation of free energy changes in solution using perturbation theory, overlap sampling, and related approximate methods. As a specific application, extensive results are provided for free energies of hydration of substituted benzenes using the OPLS-AA force field i...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Jorgensen, William L., Thomas, Laura L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2779535/
https://ncbi.nlm.nih.gov/pubmed/19936324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ct800011m
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