Progranulin is expressed within motor neurons and promotes neuronal cell survival

BACKGROUND: Progranulin is a secreted high molecular weight growth factor bearing seven and one half copies of the cysteine-rich granulin-epithelin motif. While inappropriate over-expression of the progranulin gene has been associated with many cancers, haploinsufficiency leads to atrophy of the fro...

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Detalhes bibliográficos
Main Authors: Ryan, Cara L, Baranowski, David C, Chitramuthu, Babykumari P, Malik, Suneil, Li, Zhi, Cao, Mingju, Minotti, Sandra, Durham, Heather D, Kay, Denis G, Shaw, Christopher A, Bennett, Hugh PJ, Bateman, Andrew
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2009
Assuntos:
Research article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2779192/
https://ncbi.nlm.nih.gov/pubmed/19860916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2202-10-130
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