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Telomerase Is Essential to Alleviate Pif1-Induced Replication Stress at Telomeres
Pif1, an evolutionarily conserved helicase, negatively regulates telomere length by removing telomerase from chromosome ends. Pif1 has also been implicated in DNA replication processes such as Okazaki fragment maturation and replication fork pausing. We find that overexpression of Saccharomyces cerv...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Genetics Society of America
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2778976/ https://ncbi.nlm.nih.gov/pubmed/19704012 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.109.107631 |
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