Telomerase Is Essential to Alleviate Pif1-Induced Replication Stress at Telomeres

Pif1, an evolutionarily conserved helicase, negatively regulates telomere length by removing telomerase from chromosome ends. Pif1 has also been implicated in DNA replication processes such as Okazaki fragment maturation and replication fork pausing. We find that overexpression of Saccharomyces cerv...

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Autors principals: Chang, Michael, Luke, Brian, Kraft, Claudine, Li, Zhijian, Peter, Matthias, Lingner, Joachim, Rothstein, Rodney
Format: Artigo
Idioma:Inglês
Publicat: Genetics Society of America 2009
Matèries:
Investigations
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2778976/
https://ncbi.nlm.nih.gov/pubmed/19704012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.109.107631
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