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C-Terminal Mutants of Apolipoprotein L-I Efficiently Kill Both Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense

Apolipoprotein L-I (apoL1) is a human-specific serum protein that kills Trypanosoma brucei through ionic pore formation in endosomal membranes of the parasite. The T. brucei subspecies rhodesiense and gambiense resist this lytic activity and can infect humans, causing sleeping sickness. In the case...

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Autors principals: Lecordier, Laurence, Vanhollebeke, Benoit, Poelvoorde, Philippe, Tebabi, Patricia, Paturiaux-Hanocq, Françoise, Andris, Fabienne, Lins, Laurence, Pays, Etienne
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2009
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2778949/
https://ncbi.nlm.nih.gov/pubmed/19997494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000685
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