Factor VIII-Pulsed Dendritic Cells Reduce Anti-F.VIII Antibody Formation in the Hemophilia A Mouse Model

OBJECTIVE: Hemophilia inhibitor formation is a T-cell dependent immune response to infused factor VIII (F.VIII). As immature dendritic cells (DCre) regulate immune response and promote tolerance, we evaluated F.VIII-pulsed DCre, propagated from bone marrow in the presence of GM-CSF and TGFβ, in achi...

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Bibliographic Details
Main Authors: Ragni, Margaret V., Wu, Wenhu, Liang, Xiaoyan, Hsieh, Ching-Chuan, Cortese-Hassett, Andrea, Lu, Lina
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2778316/
https://ncbi.nlm.nih.gov/pubmed/19463774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2009.02.011
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