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Vancomycin derivative with damaged D-Ala-D-Ala binding cleft binds to cross-linked peptidoglycan in the cell wall of Staphylococcus aureus
Des-N-methylleucyl-4-(4-fluorophenyl)benzyl-vancomycin (DFPBV) retains activity against vancomycin-resistant pathogens despite its damaged D-Ala-D-Ala binding cleft. Using solid-state NMR, a DFPBV binding site in the cell walls of whole cells of S. aureus has been identified. The cell walls were lab...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2008
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2778263/ https://ncbi.nlm.nih.gov/pubmed/18302341 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi702232a |
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